摄入完整和亚麻粉的食补充剂可以改善系统性炎症
Narella A Colussi1, Juan S Todaro1, Juan P Rodríguez1
1Laboratorio de Investigaciones Bioquímicas, Facultad de Medicina, Universidad Nacional del Nordeste (UNNE), IQUIBA NEA UNNE-CONICET, Corrientes, Argentina.
和亚麻面粉,富含阿尔法-烯酸 (ALA),减少了小鼠的炎症. 这些种子增强了有益的脂肪酸 (EPA,DHA) 和增强了免疫反应,支持它们的健康益处.
科学领域:
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 和亚麻种子是阿尔法-烯酸 (ALA) 的主要来源,这是抗炎性埃可萨氨酸 (EPA) 和多可萨氨酸 (DHA) 脂肪酸的前体.
- 有限的研究存在于整体和亚麻面粉在饮食环境中的抗炎潜力.
研究的目的:
- 为了研究饮食补充完整的和亚麻面粉的抗炎作用.
- 为了评估这些效应在脂聚糖 (LPS) 诱导的全身炎症的小鼠模型中.
主要方法:
- 给小鼠吃的是控制,粉或亚麻粉食.
- 分析了营养,血液学和生物化学参数.
- 组织中的量化ALA,EPA和DHA;评估NF-κB,细胞因子表达 (IL-10,IL-1β,IL-6,TNF-α) 和巨细胞吸食能力.
主要成果:
- 实验性饮食显示营养充足和增加了ALA,EPA和DHA的组织水平.
- 增强了巨细胞的细胞能力和增加了IL-10的表达.
- 减少促炎性标志物的表达:NF-κB,IL-1β,IL-6和TNF-α.
结论:
- 整体和亚麻面粉显示出显著的抗炎性质.
- 这些面粉的饮食摄入对脂肪酸概况产生积极影响,并调节炎症反应.
- 研究结果支持消费和亚麻整体面粉的健康益处和治疗潜力.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
