用于治疗癌症的二乙酸的使用:一个范围审查
Cecilia Bianchi1, Romina P Martinelli2, Viviana R Rozados2,3
1Hospital Provincial Del Centenario, Rosario, Argentina.
Medicina
|April 29, 2024
概括
二乙酸 (DCA) 通过改变瘤代谢,显示出对癌症治疗的潜力. 然而,目前的证据不足以证实DCA.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学 是一个学科.
- 药物重用 药物重用
背景情况:
- 药物再利用 (DR) 是一种为现有药物寻找新用途的策略.
- 二乙酸 (DCA) 正在研究其潜在的抗癌作用,特别是在改变瘤代谢和克服亡抵抗方面.
- 现有研究表明,DCA可能会影响癌细胞的行为,因此需要对其临床应用进行审查.
研究的目的:
- 对现有的关于使用二乙酸 (DCA) 治疗成人癌症患者的科学文献进行范围审查.
- 确定关键的研究缺口,并提供DCA在瘤学中的应用概述.
- 为了探索涉及任何剂量,频率或DCA在成人癌症患者的施用途径的研究.
主要方法:
- 在多个医学数据库中进行了全面的文献搜索:MEDLINE/PubMed,LILACS,EPISTEMONIKOS,Cochrane图书馆和临床试验.
- 包括在内的是报告任何癌症类型的成年患者接受单独或与其他药物结合使用DCA治疗的出版物.
- 所有的研究设计都被考虑纳入审查.
主要成果:
- 总共有12篇文章被纳入审查,主要是案例报告.
- 在包括的研究中观察到显著的异质性.
- 通常报告的不良事件包括喘息,可逆性毒性和肝酶升高;评估有效性证明具有挑战性.
结论:
- 目前的证据不足以确定二乙酸 (DCA) 在癌症患者的疗效.
- 缺乏可靠的数据来证实DCA在癌症治疗中的安全性.
- 需要进一步的严格研究来确定DCA在瘤学中的治疗潜力和安全性.
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