作为乳腺癌辅助治疗的阿司匹林与安慰剂:联盟A011502随机试验
Wendy Y Chen1, Karla V Ballman2, Ann H Partridge1
1Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
JAMA
|April 29, 2024
概括
在高危非转移性患者中,每日服用阿司匹林并没有改善乳腺癌复发或存活率. 由于在本研究中缺乏益处,因此不建议使用阿司匹林作为乳腺癌辅助治疗.
科学领域:
- 癌症学
- 临床试验
- 药理学
背景情况:
- 观察性研究表明阿司匹林可以改善乳腺癌的存活率.
- 对阿司匹林用于预防乳腺癌复发的前性研究有限.
研究的目的:
- 确定阿司匹林是否降低了乳腺癌幸存者的侵袭性癌症事件的风险.
- 评估阿司匹林在预防乳腺癌复发方面的有效性.
主要方法:
- 在3020名患有高风险非转移性乳腺癌的参与者中进行3期随机,安慰剂控制的双盲试验 (NCT02927249).
- 参与者每天服用300毫克阿司匹林或安慰剂,持续5年.
- 主要结果:无侵袭性疾病的存活率;次要结果:整体存活率.
主要成果:
- 由于中期分析无效,研究提前暂停.
- 阿司匹林没有显著改善无侵袭性疾病生存率 (HR,1.27;P=.06).
- 在阿司匹林组观察到的侵袭性事件数量较高,整体存活率没有差异.
结论:
- 在高危非转移性患者中,每日用阿司匹林治疗并没有改善乳腺癌复发风险或生存率.
- 根据这些发现,不建议使用阿司匹林作为乳腺癌辅助治疗.
- 可能需要进一步的研究来探索特定子组的潜在益处.
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