简短的Zwitterionic Sulfobetaine修饰的纳米粒子:中立性是可能的吗?
Gabriela Borba Mondo1,2, Marilina Cathcarth3, Gabriel S Longo3
1Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970 Campinas, Brazil.
Langmuir : the ACS journal of surfaces and colloids
|April 29, 2024
概括
兹威特离子涂层可以防止生物分子吸附. 硫贝功能化纳米颗粒 (ZS@SiO2NPs) 由于硫贝稳定了西兰醇,表现出负电荷,增强了溶液中的环状稳定性.
科学领域:
- 材料科学 材料科学 材料科学
- 表面化学 表面化学
- 纳米技术纳米技术
背景情况:
- 兹威特子涂层防止生物分子吸附,并通过其电中性和水友性质增强纳米粒子稳定性.
- 短硫乙烯是有效的防剂,减少蛋白质吸附并改善纳米粒子体稳定性.
- 尽管ZS的中性性质,但Zwitterionic sulfobetaine silane (ZS) 功能化的纳米粒子 (ZS@SiO2NPs) 显示出负电荷.
研究的目的:
- 为了彻底研究ZS@SiO2NPs的表面特性.
- 为了阐明ZS@SiO2NPs.负电荷的来源.
- 了解有助于ZS@SiO2NPs的合稳定性的因素.
主要方法:
- 为ZS@SiO2NPs.开发精细的功能化程序.
- 详细描述ZS@SiO2NPs的表面特性.
- 建模以解决表面特征问题和在不同pH值和离子强度条件下评估体稳定性.
主要成果:
- ZS@SiO2NPs的负电荷来自于硫贝结构中的四级氨基通过四级氨基稳定残余表面醇中的氧化.
- 零电荷ZS@SiO2NP是不太可能的,因为增加了silanol解离和负电荷.
- 在较高的离子强度下,ZS@SiO2NPs表现出增强的体稳定性,这表明与盐离子的相互作用可以防止聚合.
结论:
- 该研究澄清了ZS@SiO2NPs中负面电荷的起源.
- 这些发现突出了硫贝结构在稳定西拉和影响纳米粒子电荷方面的作用.
- 这项研究提供了关于复杂介质中zwitterionic纳米粒子显著的合稳定性的见解,特别是在高离子强度下.
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