在社区护理中心中实施临床试验的障碍
Hedyeh Ebrahimi1, Sandra Megally2, Elana Plotkin2
1City of Hope Comprehensive Cancer Center, Duarte, California.
JAMA network open
|April 29, 2024
概括
许多癌症患者希望加入临床试验,但很少有人报名. 这项研究确定了社区瘤学设置中的关键障碍,突出了临床试验获取的差异和对癌症研究更好地招募患者的未满足需求.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
背景情况:
- 大多数癌症患者对临床试验表达了兴趣,但入学率仍然很低.
- 识别临床试验参与障碍对于改善患者获得新型癌症疗法至关重要.
研究的目的:
- 识别癌症临床试验招生中的关键障碍.
- 为了告知实践变化,可以增加患者参与临床试验.
主要方法:
- 一项由34个问题组成的调查被分发给全国的瘤诊所.
- 该调查评估了人口统计特征,临床试验操作和转诊实践.
- 参与者包括参与ACCC/ACORI活动的场所,ASCO-ACCC试点场所或为少数群体提供服务的场所.
主要成果:
- 在接受调查的癌症中心中,58%完成了调查;88%进行治疗临床试验.
- 与城市实践相比,农村实践提供了较少的第一阶段试验 (25%对67%).
- 关键障碍包括患者招募的挑战,有限的员工数量,无关的试验,以及基础设施和资金不足.
结论:
- 在不同的社区瘤学环境中,临床试验的可用性存在显著差异.
- 试验支持基础设施的缺陷阻碍了研究活动,并限制了患者的访问.
- 解决这些未满足的需求对于瘤诊所有效提供临床试验至关重要.
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