磁性治疗与双极躁狂患者的改性电治疗:一项随机临床试验
Shan Chen1,2, Jianhua Sheng1, Fuzhong Yang1
1Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
JAMA network open
|April 29, 2024
概括
磁性疗法 (MST) 显示为对双相躁狂的电疗法 (ECT) 的替代方案,提供类似的有效性,潜在的认知副作用较少. 这项研究突出了MST的重点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 双极性躁狂是一种致残的疾病,通常用电疗法 (ECT) 治疗.
- 虽然ECT是有效的,但它会带来认知不良影响的风险.
- 磁性治疗 (MST) 之前没有被报道为治疗双相躁狂症.
研究的目的:
- 为了比较MST与ECT在双相躁狂患者中的疗效和认知副作用.
- 评估MST作为一种潜在的替代品来治疗严重的躁狂症.
主要方法:
- 一项随机临床试验,涉及上海精神卫生中心48名双相躁狂患者.
- 参与者接受了MST或ECT,持续了8-10次.
- 主要结局包括年轻躁狂评分表 (YMRS) 评分下降和响应率,使用治疗意图 (ITT) 和重复措施ANOVA进行分析.
主要成果:
- 无论是MST还是ECT,都显示出高响应率 (86.4%的MST,95.0%的ECT),两组之间没有显著差异.
- 在MST和ECT之间,YMRS的减少率也是可比的.
- 认知功能,特别是语言领域的认知功能,在MST组比ECT组更好地保存.
结论:
- 双极性躁狂是一种可行的替代性治疗方法,MST的疗效与ECT相当.
- 通过尽量减少认知障碍,特别是语言功能方面的认知障碍,MST可能提供显著的优势.
- 进一步的研究支持MST作为一个潜在的更安全和同样有效的选择来管理严重的躁狂.
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