在糖尿病,高血压和动脉样硬化中的真空H+-ATPase
Na Wang1,2, Liwei Ren1,3, A H Jan Danser1
1Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
Microcirculation (New York, N.Y. : 1994)
|April 29, 2024
概括
空腔H+-ATPase (V-ATPase) 调节细胞pH,并参与信号传递. 这篇评论探讨了其在血管疾病 (如高血压和动脉样硬化) 以及糖尿病并发症中的有限作用.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
背景情况:
- 空腔H+-ATPase (V-ATPase) 是一个重要的质子,调节细胞区和细胞外空间的pH值.
- V-ATPase对于受体介导的信号通路至关重要.
- 虽然研究了V-ATPase在癌症,骨质疏松症和神经退行性疾病中的作用,但其在血管疾病中的参与程度不明.
研究的目的:
- 审查V-ATPase在高血压和动脉样硬化中的作用.
- 探索V-ATPase对糖尿病血管并发症的贡献.
- 讨论针对血管疾病的V-ATPase的药理潜力.
主要方法:
- 对V-ATPase现有研究的文献综述.
- 分析与血管疾病相关的V-ATPase结构和功能.
- 在疾病背景下探索V-ATPase在信号和pH调节中的作用.
主要成果:
- 维-ATPase在调节pH和与高血压和动脉样硬化相关的信号传递方面发挥作用.
- V-ATPase通路与糖尿病相关的血管并发症有关.
- 向V-ATPase为血管疾病提供了潜在的治疗策略.
结论:
- V-ATPase是血管健康和疾病的重要因素.
- 需要对血管疾病中的V-ATPase机制进行进一步的研究.
- 对V-ATPase的药理向可能为高血压,动脉样硬化和糖尿病血管并发症提供新的治疗方法.
更多相关视频
08:22Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
Published on: March 20, 2017
8.7K
08:31Fluorescence Microscopy for ATP Internalization Mediated by Macropinocytosis in Human Tumor Cells and Tumor-xenografted Mice
Published on: June 30, 2021
2.8K
相关概念视频
01:30ATP Driven Pumps III: V-type Pumps
3.7K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
3.7K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
621
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
621
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
716
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
716
01:34ATP Driven Pumps II: P-type Pumps
4.8K
The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
4.8K
01:27ATP Driven Pumps I: An Overview
8.1K
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
8.1K
01:18Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K