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含有聚乙烯比古安化的杀菌性伤口清洁和灌溶液的安全性和有效性
Mark G Rippon1,2, Kristian Daly3, Alan A Rogers4
1Huddersfield University, Huddersfield, UK.
Journal of wound care
|April 29, 2024
概括
含有聚乙烯比古安化物 (PHMB) 的HydroClean Solution显示出与其他伤口灌溶液相比的安全性. 它没有对3D皮肤模型中的组织活力或炎症标志物产生负面影响,促进了新的组织生长.
科学领域:
- 伤口愈合研究研究研究.
- 生物材料科学是生物材料的科学.
- 皮肤病学 皮肤病学
背景情况:
- 伤口清洁和灌溶液通常含有抗菌剂.
- 评估这些解决方案的安全性和有效性对于有效的伤口管理至关重要.
- 聚乙烯比古安化物 (PHMB) 是一种常见的抗菌剂,用于伤口护理产品.
研究的目的:
- 为了评估HydroClean Solution的安全性,含PHMB的灌溶液.
- 评估HydroClean Solution对3D全厚人体皮肤伤口模型的影响.
- 为了比较HydroClean Solution的细胞毒性与其他商业可用的伤口灌解决方案.
主要方法:
- 使用L929小鼠纤维细胞的细胞毒性测定 (ISO 10993-5:2009).
- 在体外3D全厚人体皮肤伤口模型.
- 乳酸脱酶 (LDH) 对组织活力的测定.
- 干白素-6 (IL-6) 试验用于促炎作用.
主要成果:
- HydroClean Solution表现出与其他商业灌溶液相当的细胞毒性.
- 与对照组相比,3D皮肤模型中没有观察到LDH或IL-6水平的显著差异.
- 在3D皮肤模型的周围区域观察到显著的组织加厚.
结论:
- 液体清洁液具有与现有的伤口灌解决方案相提并论的安全性.
- 该溶液不会对组织活力产生不利影响,也不会在3D人体皮肤模型中诱导炎症反应.
- HydroClean Solution可能会刺激周围伤口区域的新组织生长.
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