来自Platycodon grandiflorus根的两个新的含N的异环化合物
Lan Ding1, Xin-Yin Cai2, Ren-Nai Yang1
1School of Pharmacy, Anhui University of Chinese Medicine, Hefei, PR China.
Natural product research
|April 29, 2024
概括
从Platycodon grandiflorus的根中分离出了两种含的新型异环化合物,即Plagranlines B-C. 这些化合物在糖酶,雌激素类和氧化测定中表现出弱抑制活性.
科学领域:
- 自然产品化学 自然产品化学
- 有机化学 有机化学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 普拉蒂科登格兰迪佛鲁斯是一种传统的药用植物.
- 含的异环化合物在药物发现中具有重要意义.
- 隔离具有独特结构特征的新型化合物对于扩大化学多样性至关重要.
研究的目的:
- 从Platycodon grandiflorus根源中分离和描述新的含N的异环化合物.
- 为了阐明结构,并确定绝对配置的分离化合物.
- 评估新化合物的生物活性.
主要方法:
- 使用色谱技术进行隔离和净化.
- 通过核磁共振 (NMR) 光谱和高分辨率电喷射电离化质谱法 (HRESIMS) 阐明结构.
- 使用量子化学计算 (GIAO 13C NMR (DP4+) 和 ECD计算) 确定绝对配置.
- 生物活性查,包括糖酶,类似雌激素和氧化抑制试验.
主要成果:
- 分离了两个不寻常的含有N的异环化合物,即Plagranlines B (1) 和C (2).
- 普拉格兰林B (1) 具有新林和氨酸单元; 普拉格兰林C (2) 含有一种罕见的里丁环.
- 结构通过光谱数据得到确认,绝对配置通过计算方法得到确认.
- 化合物1和2在测试试验中表现出较弱的活性.
结论:
- 这项研究成功地分离和表征了来自Platycodon grandiflorus的两种新型含N的异环化合物.
- 结构阐明采用了先进的光谱和计算技术.
- 虽然这些化合物表现出微弱的生物活性,但它们有助于了解自然产品的化学多样性,并可能成为进一步研究的线索.
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