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切莱科克西布治疗疼痛的处方是否会影响桃体切除术后需要手术的出血? 一个回顾性的观察性队列研究
Vincent So1, Dhenuka Radhakrishnan2, Johnna MacCormick3
1Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Anesthesiology
|April 29, 2024
概括
切莱科克西布在儿科研究中没有显著增加需要手术的桃体切除术后出血的风险. 这一发现表明,切莱科克西布是桃体切除术后治疗疼痛的安全选择.
科学领域:
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
- 临床结果 临床结果
背景情况:
- 桃体切除术是一种常见的儿科手术,有出血和疼痛的风险.
- 非类固醇抗炎药物 (NSAID) 用于疼痛,但引起出血的担忧.
- 选择性循环氧化酶-2 (COX-2) 抑制剂,如赛莱科西布,可以在不增加出血风险的情况下提供疼痛缓解.
研究的目的:
- 为了研究术后的赛莱科克西布处方和需要手术的桃体切除术后出血之间的关联.
- 评价儿童桃体切除术患者中关于手术出血并发症的赛莱科西布的安全性.
主要方法:
- 对接受桃体切除 (2007-2017) 的儿童 (<18岁) 的回顾性观察队列研究.
- 主要结局:桃体切除术后出血需要手术的患者比例.
- 使用治疗权重的逆概率和通用估计方程来分析赛莱科西布与出血的关联.
主要成果:
- 包括5,846名儿童;28.1%接受了赛莱科西布.
- 1.7%的桃体切除术患者经历了需要手术的出血.
- 没有发现赛莱科克西布处方与桃体切除术后出血的几率增加 (OR=1.4,P=0.20) 之间有显著的关联.
结论:
- 切莱科西布并没有显著增加桃体切除术后需要手术的出血风险.
- 这项研究为儿童桃体切除术中赛莱科西布的安全性提供了证据.
- 建议通过多站点随机对照试验进一步确认.
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