系统性硬化症患者感知到的消化功能障碍的严重程度和影响:一个横截面研究
Laura Cano-García1,2, Rocío Redondo-Rodríguez1,2, Natalia Mena-Vázquez3,2
1Reumatología, Hospital Regional Universitario de Málaga, Malaga, Spain.
BMJ open
|April 29, 2024
概括
系统性硬化症 (SSc) 患者经常出现严重的胃肠道问题,影响他们的生活质量和营养状况. 这些症状与更显著的皮肤纤维化和营养不良有关.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 临床医学 临床医学
背景情况:
- 系统性硬化症 (SSc) 是一种多系统的自身免疫性疾病,其特征是皮肤和内脏的纤维化.
- 胃肠道 (GI) 的参与在SSc中很常见,并且可以显著影响患者的发病率和生活质量.
研究的目的:
- 评估SSc患者胃肠道症状的严重程度和影响.
- 在SSc.中识别与肠道干预和消化不良相关的因素.
主要方法:
- 一项涉及75名SSc患者的横截面研究.
- 用UCLA SCTC GIT 2.0仪器测量了胃肠道症状的严重程度.
- 使用EAT-10评估失调症,使用MNA-SF评估营养状况. 用mRSS评估皮肤纤维化.
主要成果:
- 超过一半的SSc患者报告中度至严重的逆流 (58.7%) 或便秘 (57.4%).
- 胃肠道症状显著影响了社会功能 (42.7%) 和情绪健康 (40.0%).
- 缺食症影响了52%的患者,营养不良存在于30.7%的患者中.
结论:
- 在SSc患者中,严重的胃肠道症状很普遍.
- 胃肠道干扰与更差的生活质量,增加皮肤纤维化和营养不良有关.
- 早期识别和管理胃肠道症状对于SSc患者护理至关重要.
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