相关实验视频
Updated: Jun 27, 2025

09:49
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
15.9K
关于血液产品中MMA水平与捐赠者的性别,年龄和捐赠频率之间的关系
Fei Li1, Aiwei Zhu1, Caixia Huang1
1Changzhou Blood Center.
Journal of nutritional science and vitaminology
|April 29, 2024
概括
甲基马龙酸 (MMA) 含量在红细胞中高于血,但与捐赠者的年龄或捐赠频率没有显著差异. 血液制品中的MMA水平对中国的癌症患者来说是安全的.
科学领域:
- 生物化学 生化学
- 血液学 血液学 血液学
- 老年学是指老年学的学科.
背景情况:
- 人口老龄化增加了老年献血者的比例.
- 甲基马龙酸 (MMA) 是酸代谢的副产品,在老年人中可能会增加.
- 在慢性疾病和瘤进展中MMA的作用需要研究其在血液制品中的水平.
研究的目的:
- 为了确定血液产品中MMA的绝对度.
- 分析捐赠者的年龄,性别和捐赠频率对MMA水平的影响.
- 评估有关MMA的血液制品对输血接受者,特别是癌症患者的安全性.
主要方法:
- 液体染色学-并联质谱学 (LC-MS/MS) 用于MMA量化.
- 分析包括新鲜血和白细胞稀缺悬浮红细胞 (lds-RBCs).
- 献血者按年龄,性别和献血频率进行分类.
主要成果:
- 与新鲜血相比,MMA含量在lds-RBC中显著更高 (p<0.0001).
- 不同年龄组或捐赠频率之间没有观察到MMA水平的显著差异.
- 在lds-RBC中,男性的MMA水平高于女性 (p=0.035),但在新鲜血中没有.
结论:
- 中国血制品中的MMA含量不会影响癌症患者的输血安全.
- 需要进一步的研究来确定MMA的特定种族和特定年龄的正常参考范围.
- 在特定人群中监测MMA水平可能是合理的.
更多相关视频
10:11Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
Published on: March 7, 2013
15.4K
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
7.3K
相关概念视频
Blood Transfusion
549
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
549
Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
Bone Marrow Sampling and Transplants
326
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
326
Tissue Transplantation
360
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
360
Blood Types
17.6K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.6K
The ABO Blood Group
1.7K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
1.7K