相关实验视频

Updated: Jun 27, 2025

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

一种酸敏铁基纳米复合物用于OSCC治疗

X Zhao¹, D Leng¹, H Wang¹

¹Jiangsu Province Key Laboratory of Oral Diseases & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine & Department of Endodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.

Journal of dental research

|April 29, 2024

概括

这项研究引入了一种新的基于铁的纳米复合材料,USPBNPs@MCSNs,用于口腔状细胞癌 (OSCC) 治疗. 它通过诱导铁亡,有效地抑制OSCC的生长和转移,提供了一个有前途的新疗法策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

口腔状细胞癌 (OSCC) 由于其侵袭性和转移潜力,存在重大治疗挑战.
瘤微环境的独特特征,如温和的酸度和高的H2O2水平,提供治疗机会.
针对OSCC的向治疗仍然有限,需要创新的治疗方法.

研究的目的:

开发一种对酸有反应的铁基纳米复合材料,用于针对性的OSCC治疗.
研究开发的纳米复合材料在抑制OSCC扩散,入侵和转移方面的有效性.
阐明由纳米复合材料诱导的OSCC细胞死亡的潜在机制.

主要方法:

将超小的普鲁士蓝色纳米粒子 (USPBNPs) 装入中孔酸纳米粒子 (MCSNs) 中,以创建USPBNPs@MCSNs (UPM).
评估UPM在酸性和中性环境中的双酶活性.
评估UPM对OSCC细胞增殖,迁移,入侵和小鼠体内瘤生长的影响.
分析分子机制,包括通过xCT/GPX4/谷氨 (GSH) 轴诱导铁灭.

主要成果:

UPM表现出优异的双酶活性,在酸性条件下产生有毒的基基 (·OH),在中性条件下产生氧 (O2).
在小鼠中,UPM有效地抑制了OSCC细胞的增殖,迁移,入侵,并减少了小鼠的瘤生长,系统毒性最小.
发现UPM通过降低xCT/GPX4/谷氨 (GSH) 轴的调节来诱导OSCC细胞中的铁亡,从而导致特征性的细胞变化.

结论:

USPBNPs@MCSNs (UPM) 是一个有前途的纳米复合物用于口腔状细胞癌治疗.
通过诱导铁亡,UPM有效地准OSCC,提供了一种新的治疗途径.
这项研究提供了强有力的证据,证明铁化作为OSCC的可行的治疗点.

关键词:

催化酶的催化剂是什么铁性化 (ferroptosis) 是一种纳米颗粒是一种纳米粒子.口腔状细胞癌的癌症.过氧化酶的使用有活性氧物种的反应性氧物种.

更多相关视频

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo

Published on: February 5, 2019

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...