在患有炎症性肠病的绝经后妇女中,心血管不良结果的风险
Ruby Greywoode1, Joseph Larson2, Jellyana Peraza3
1Division of Gastroenterology, Montefiore Medical Center/Albert Einstein College of Medicine, 111 East 210th St, Bronx, NY, 10467, USA. rgreywoode@montefiore.org.
Digestive diseases and sciences
|April 29, 2024
概括
患有炎症性肠病 (IBD) 的女性在绝经后可能面临更高的缺血性中风风险. 需要进一步的研究来证实这一关联,并了解其对心血管疾病 (CVD) 预防的影响.
科学领域:
- 心血管健康 心血管健康
- 胃肠病学 胃肠病学
- 妇女健康 妇女健康
背景情况:
- 患有炎症性肠病 (IBD) 的人经常出现不良心血管疾病 (CVD) 结果,即使没有传统的危险因素.
- 绝经后患有IBD的女性心血管疾病风险在很大程度上仍未得到研究.
研究的目的:
- 研究绝经后妇女的IBD和心血管疾病风险之间的关联.
- 为了确定患有IBD的女性在更年期后是否有特定心血管事件的风险增加.
主要方法:
- 对妇女健康倡议 (WHI) 参与者进行了生存分析.
- 考克斯的比例危险模型被用来评估患有IBD和没有IBD的女性之间的冠心病 (CHD),缺血性中风,静脉血栓塞栓症 (VTE) 和外周动脉疾病 (PAD) 的风险.
- 模型被调整为许多人口统计学,并发症和生活方式因素.
主要成果:
- 该研究包括134,022名参与者,其中1.0%报告IBD.
- 在IBD和非IBD妇女之间,在CHD,VTE或PAD风险上没有发现显著差异.
- 最初在IBD女性中观察到有统计学意义的缺血性中风风险较高,但随着进一步的调整,这种风险减弱了.
结论:
- 患有IBD的绝经后妇女可能患有缺血性中风的风险较高.
- 这些发现表明IBD与绝经后妇女的脑血管风险之间存在潜在联系,需要进一步调查.
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