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Updated: Jun 27, 2025

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
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Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

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在成年哺乳动物组织中,PARKIN不需要维持OXPHOS功能

Roberta Filograna1, Jule Gerlach2, Hae-Na Choi3,4

  • 1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. roberta.filograna@ki.se.

NPJ Parkinson's disease
|April 29, 2024
PubMed
概括

帕金斯基因 (PRKN) 缺乏不会影响线粒体功能或导致成年小鼠或患者的神经退行,挑战其在帕金森病病原和线粒体质量控制中的既定作用.

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Peroxisomes

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Peroxisomal Protein Import:
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Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
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