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基于氨酸聚胺的新型合成纳米颗粒的临床前评估,以改善向肺部输送

Eman Zmaily Dahmash¹, Nour Radwan Achkar², Dalia Khalil Ali³

¹Department of Chemistry and Pharmaceutical Sciences, School of Life Sciences, Pharmacy and Chemistry, Kingston University, London, KT1 2EE, UK. e.dahmash@kingston.ac.uk.

Scientific reports

|April 29, 2024

概括

纳米技术通过创建统一,可重复的固定剂量组合吸入器来增强喘治疗. 新型纳米颗粒改善了药物向肺部的输送,为有效管理喘提供了优越的替代方案.

科学领域:

制药纳米技术制药纳米技术
药物输送系统药物输送系统
材料科学材料科学材料科学

背景情况:

单个吸入器中的固定剂量组合 (FDC) 改善了患者对呼吸系统疾病的遵守.
为FDCs开发统一和可重复的干粉吸入器 (DPI) 提出了重要的配方挑战.

研究的目的:

开发一种基于纳米技术的FDC DPI,使用酸 (FP) 和沙米特醇酸 (SAL) 治疗喘.
解决FDCDPI中的配方统一性和可重复性问题.

主要方法:

药物装载纳米颗粒的制备,使用一种新型的基于氨酸的聚胺 (聚胺) 通过单步界面聚合.
包括内容统一性,粒子大小分析 (PSA),FTIR,TEM,DSC,XRD和空气动力学性能评估在内的全面表征.
在体外和体内对优化纳米粒子配方的评估.

主要成果:

高药物捕获效率 (>90%) 在优化的纳米粒子配方中实现.
与市场上销售的产品相比,其优越的空气动力学性能 (排放剂量,微粒分数,可呼吸剂量).
在体内小鼠研究中,可重复的FP和SAL向肺部输送,FP水平超过了市场配方.

结论:

通过一阶段工艺制备的新型FDC FP/SAL纳米颗粒显示出卓越的性能.
这种纳米技术方法为喘管理提供了一种具有成本效益和效率的方法.
开发的纳米粒子增强了FDC DPIs的药物输送和可重复性.

关键词:

干粉吸入器干粉吸入器流动松 propionate 的使用情况接口多重凝聚方式萨尔米特 (Salmeterol xinafoate) 是一种天然的药物.基于氨酸的聚 (胺) .

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