多发性硬化和COVID后疾病的认知特征:使用统一分类的比较研究
Cristina Delgado-Alonso1, Alfonso Delgado-Alvarez1, María Díez-Cirarda1
1Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria "San Carlos" (IdISSC), C/Profesor Martín Lagos, 28040, Madrid, Spain.
Scientific reports
|April 29, 2024
概括
后COVID状态 (PCC) 和多发性硬化症 (MS) 呈现出类似的认知障碍,特别是在注意力和处理速度方面. 虽然疲劳在PCC中更为严重,但它与MS患者的认知缺陷更为密切相关.
科学领域:
- 神经学 神经学
- 神经免疫学 神经免疫学
- 认知科学 认知科学
背景情况:
- 后COVID疾病 (PCC) 和多发性硬化症 (MS) 分享重叠的症状,如认知功能障碍和疲劳.
- 参与MS的病理生理机制,包括神经炎症和自身免疫力,也在PCC中被建议.
- 了解共同和独特的特征对于诊断和治疗至关重要.
研究的目的:
- 为了比较PCC和MS患者的大队伍之间的认知表型.
- 在这两种条件下,研究疲劳严重程度和认知表现之间的关系.
- 识别潜在的共同或分歧的潜在机制.
主要方法:
- 横截面研究设计. 截面研究设计.
- 包括218名PCC患者和218名MS患者,根据年龄,性别和教育情况进行匹配.
- 综合的神经心理评估,疲劳和抑郁症评估,并使用国际认知障碍分类进行分类.
主要成果:
- PCC和MS的认知概况在很大程度上重叠,注意力和处理速度是两个领域中受影响最大的领域.
- 情节性记忆障碍在MS中略大,尽管效果大小小.
- 疲劳严重程度在PCC中更高,但其与认知表现的相关性在MS中更明显.
- 两组之间没有观察到抑郁症严重程度的显著差异.
结论:
- 现在的PCC和MS具有相似的认知特征,突出显示了共同的神经影响.
- 疲劳是PCC中更突出的症状,但在MS中与认知缺陷的联系更强.
- 在这些条件下对认知功能障碍和疲劳的机制进行进一步的研究是治疗进步的必要条件.
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