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Updated: Jun 27, 2025

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CBX3对抗IFNγ/STAT1/PD-L1轴以调节结肠炎症和CRC化学敏感性

Yao Xiang1, Jorge Mata-Garrido1, Yuanji Fu1

  • 1Université Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, F-75015, Paris, France.

EMBO molecular medicine
|April 29, 2024
PubMed
概括

表观遗传调节器CBX3通过抑制STAT1和PD-L1.1,抑制结肠中的干扰素- (IFNγ) 信号传递. 删除CBX3会引起炎症,并增强结肠直肠癌 (CRC) 对IFNγ和化疗的敏感性.

关键词:
在CBX3 (HP1γ) 中.科伦·科伦 (Colon Colon) 是指一个结肠.结肠直肠癌是什么意思IFNγ 信号传输 IFNγ 信号传输炎症/免疫反应

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