营养干预措施以预防早产性视网膜病变
Ann Hellström1, Elsa Kermorvant-Duchemin2, Mark Johnson3,4
1Department of Clinical Neuroscience, Institution of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. ann.hellstrom@medfak.gu.se.
Pediatric research
|April 29, 2024
概括
优化非常早产婴儿的营养,特别是用阿拉基酸 (ArA) 和 docosahexaenoic 酸 (DHA),可以降低早产视网膜病变 (ROP) 的风险. 早期肠道补充剂显著降低了严重的ROP发病率.
科学领域:
- 新生儿营养新生儿营养
- 儿科眼科 儿科眼科
- 产周医学 产周医学
背景情况:
- 非常早产的婴儿面临生长衰竭和早产视网膜病变 (ROP) 的高风险.
- 营养优化,特别是门和肠道养,对于生长和减少ROP至关重要.
- 阿拉基酸 (ArA) 和多可萨赫萨酸 (DHA) 是早产婴儿出生后失去的重要营养素.
研究的目的:
- 审查营养干预措施,以预防早产婴儿的ROP.
- 为了突出ArA和DHA的肠道补充对ROP发生率的影响.
- 专注于ROP预防,区别于对其他早产发病的审查.
主要方法:
- 对新生儿肠道补充剂随机对照试验的分析.
- 对研究ArA和DHA对ROP的影响的评估.
- 补充剂水平与胎儿增长率的比较.
主要成果:
- 早期肠道补充ArA (100 mg/kg/d) 和DHA (50 mg/kg/d) 可将严重的ROP降低50%.
- 较高的氨基酸摄入量与较低的高血糖症有关,这是ROP的危险因素.
- 强化母乳对ROP有剂量依赖的预防作用.
结论:
- 新生儿肠道补充ArA和DHA,模仿胎儿增殖率,有效地将严重的ROP降低50%.
- 营养策略是管理非常早产婴儿ROP的关键.
- 进一步研究特定营养对ROP的影响是有必要的.
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