建模溢出动态:了解公众健康关注的新兴病原体
Fernando Saldaña1, Nico Stollenwerk1,2, Joseba Bidaurrazaga Van Dierdonck3
1Basque Center for Applied Mathematics (BCAM), Bilbao, Spain.
Scientific reports
|April 29, 2024
概括
新兴的传染病,通常是动物传染病,对全球健康构成风险. 数学建模显示,虽然大多数溢出事件不会导致人类持续的流行病,但频率增加可能导致严重的疫情爆发,需要预防流行病.
科学领域:
- 流行病学 流行病学
- 数学生物学 数学生物学
- 公共卫生 公共卫生
背景情况:
- 新兴传染病 (EIDs) 构成了全球重大卫生挑战.
- 大约60%的EID是动物传染病,起源于动物和人类之间的病原体溢出事件.
- 了解溢出事件的复杂动态对于疫情准备至关重要.
研究的目的:
- 开发一个数学模型模拟动物传染病溢出.
- 调查影响跨物种传播和疫情动态的因素.
- 提供关于新型病原体大规模流行病的潜力的见解.
主要方法:
- 采用了一个连续时间随机建模框架.
- 该模型将动物水库和人类宿主动态联系起来.
- 数字实验探索了各种溢出场景和参数变化.
主要成果:
- 大多数新的动物性传染病原体爆发不会在人类群体中持续存在.
- 然而,越来越频繁的溢出事件可能会导致大量的,意想不到的疫情爆发.
- 动态表明,即使是罕见的事件,如果经常发生,也可能对公共卫生产生重大影响.
结论:
- 流行病预防战略必须解决动物传染病溢出事件日益增加的风险.
- 减少溢出频率与控制出现后的疫情一样重要.
- 需要采用综合方法来减轻EID的影响.
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