人类疹病毒8感染在男性比女性更常见吗? 一个更新的元分析
Haibo Gong1, Shuai Zhang2, Jinfa Dou2
1Department of Dermatology, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Zhengzhou, Zhengzhou, Henan, 450003, China. gonghaibo2019@163.com.
BMC infectious diseases
|April 29, 2024
概括
与女性相比,男性感染人类疹病毒8 (HHV-8) 的风险略高,特别是在全球和撒哈拉以南非洲的成年人群中. 在儿童中没有观察到HHV-8感染的性别差异.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 卡波西肉瘤 (KS) 主要影响男性.
- 卡波西的肉瘤相关性疹病毒 (KSHV) 或人类疹病毒8 (HHV-8) 是导致KS的主要原因.
- 调查基于性别的HHV-8感染易感性对于了解KS流行病学至关重要.
研究的目的:
- 评估一般人群中性别和HHV-8血清阳性之间的关联.
- 为了确定男性是否比女性更容易感染HHV-8病毒.
- 分析不同年龄组和地理区域的HHV-8感染的性别差异.
主要方法:
- 进行了全面的元分析.
- 搜索了六个主要的在线数据库,查找2023年3月15日之前发表的相关研究.
- 包括33篇文章,包括41项研究进行分析.
主要成果:
- 在全球范围内,成年男性感染HHV-8的风险略高于女性 (OR:1.08,95%CI:1.01-1.15).
- 在撒哈拉以南非洲成年人群中观察到显著的性别差异 (OR:1.15,95% CI:1.05-1.26).
- 在全球或撒哈拉以南非洲的儿童群体中,在亚洲,欧洲或美国的成人群体中,在HHV-8感染中没有发现显著的性别差异.
结论:
- 在成年人群中对HHV-8感染存在轻微的性别差异.
- 在全球和撒哈拉以南非洲,男性感染HHV-8的可能性高于女性.
- 建议进行进一步的标准化研究,以加强这些关于性别和HHV-8感染的发现.
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