在一项队列研究中,第一季度的胎儿大小,子宫加速生长和儿童神经发育
Xinmei Chen1, Hongxiu Liu1, Yuanyuan Li1
1Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
BMC medicine
|April 29, 2024
概括
第一个三个月的胎儿大小会影响儿童的神经发育. 怀孕早期的受限生长与发育迟缓有关,尽管加速的子宫内生长可能会改善精神发育.
科学领域:
- 神经发育研究的神经发育研究.
- 产前发育 产前发育
- 儿科卫生健康 儿科卫生健康
背景情况:
- 早期怀孕对于胎儿神经系统发育至关重要.
- 第一个三个月的胎儿大小与后来的神经发育之间的联系需要进一步研究.
- 了解这些关联可以为最佳儿童发展提供干预信息.
研究的目的:
- 为了检查第一季度胎儿大小与2岁时神经发育之间的关联.
- 为了确定加速子宫内生长是否可以减轻受限制的早期胎儿生长的影响.
- 为儿童神经发育结果的早期预测因素提供见解.
主要方法:
- 在中国武汉的一组2058个胎儿,测量了第一季度的冠状长度 (CRL).
- 胎儿生长模式根据预计的胎儿体重增长率从怀孕中期到晚期进行分类.
- 神经发育被评估在2岁使用贝利婴儿发育尺度的中国修订.
主要成果:
- 第一季度CRL增加与2岁时更高的精神和精神运动发育指数得分有关.
- 第一季度受限的胎儿尺寸与发育迟缓相关.
- 早期尺寸受限制的胎儿的子宫内增长加速改善了精神发育得分,但不是精神运动得分.
结论:
- 第一个三个月限制胎儿尺寸与儿童的精神和精神运动发育受损有关.
- 宫内加速生长可能部分改善受影响儿童的精神发育.
- 建议对不同种群进行进一步的研究,以验证这些发现.
相关概念视频
Nature and Nurture
20.5K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.5K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K


