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由Prevotella heparinolytica引起的耐火性肺炎:一个病例报告

Jiongzhou Sun¹, Xun Xu², Shiyuan Gao¹

¹Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

Journal of medical case reports

|April 29, 2024

概括

通常在动物中发现的一种细菌Prevotella heparinolytica,在人类患者中引起了耐火性肺炎. 甲基因组测序确定了病原体,指导有效的抗生素治疗用皮佩拉西林-塔扎巴克坦和奥尔尼达.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
肺部病理学肺部病理学

背景情况:

普雷沃特拉 (Prevotella heparinolytica) 是一种已知存在于动物呼吸道中的格拉姆阴性细菌.
这种细菌具有肝素分解活性和毒性因子,有助于马的疾病.
人类感染Prevotella heparinolytica的病例,特别是肺炎,以前没有被记录.

研究的目的:

报告了第一个已记录的Prevotella heparinolytica在人类中引起肺炎的病例.
突出元基因组下一代测序在诊断罕见感染中的实用性.
为了证明耐火性肺炎的有效治疗策略,由不寻常的病原体引起的.

主要方法:

一名58岁的男性患者出现了持续的咳,发烧和双侧肺不透明.
最初的莫西弗洛克萨治疗无效.
通过下一代元基因组测序来确立诊断,识别了Prevotella heparinolytica.

主要成果:

患者的症状不适应标准抗感染疗法.
甲基因组分析确定了Prevotella heparinolytica作为致病剂.
将抗生素切换为piperacillin-tazobactam和ornidazole导致症状缓解和放射性改善.

结论:

普雷沃特拉 (Prevotella heparinolytica) 可以作为一种机会性病原体,在人类中引起肺炎.
甲基因组下一代测序是识别耐火性肺炎病原体的宝贵工具.
快速识别病原体有助于指导适当的抗生素选择和患者管理.

关键词:

这种植物是Prevotella heparinolytica.转基因组学的下一代测序.口腔感染口腔感染肺炎是一种肺炎.

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