在5个未翻译区域的差异凸显了对剂量敏感基因的翻译调节的重要性

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Updated: Jun 27, 2025

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Nechama Wieder1,2, Elston N D'Souza1,2, Alexandra C Martin-Geary1,2

  • 1Big Data Institute, University of Oxford, Oxford, UK.

Genome biology
|April 29, 2024
PubMed
概括

对功能丧失不耐受的基因具有更长的5'未翻译区域 (UTR),具有更多的调控元素. 这表明5' UTRs在调节基因剂量敏感性和疾病方面发挥着关键作用.

关键词:
5未翻译的地区.5 UTR 其他剂量敏感性 剂量敏感性功能丧失 - 功能丧失.翻译法规的翻译法规上游开放的阅读框架.在 uORF 的情况下.

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