在遗传学研究中包括严重和持久的厌食症神经性表型:一个范围审查
Sarah Ramsay1, Kendra Allison2, Heide S Temples2
1Healthcare Genetics and Genomics Program, School of Nursing, Clemson University, Clemson, SC 29634, USA. sramsay@clemson.edu.
Journal of eating disorders
|April 29, 2024
概括
严重持续性神经性厌食症的遗传学研究受到不一致的参与者识别的阻碍. 包括这些患者在内对于理解遗传风险和开发有效治疗方法至关重要.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 心理健康 心理健康
背景情况:
- 神经性厌食症 (AN) 的死亡率很高,康复率很低,许多人患有严重的,持久的形式.
- 遗传学研究对于了解AN的发展和持久性至关重要.
- 在遗传学研究中包括严重持久性AN (SE-AN) 患者至关重要.
研究的目的:
- 确定定义SE-AN的标准.
- 对SE-AN参与者纳入的遗传学文献进行审查.
- 评估SE-AN纳入对AN遗传学研究的影响.
主要方法:
- 系统的文献搜索 (2012-2023) 在PubMed,PsycINFO,科学网.
- 关于研究选择的PRISMA-ScR指南.
- 自2017年以来,根据文献频率定义了SE-AN标准.
主要成果:
- 普遍存在的SE-AN标准:患病≥7年,耐治疗性,极低的BMI,显著的心理/行为影响.
- 在遗传学研究中不一致地识别和纳入SE-AN参与者.
- 缺乏标准化的标准阻碍了SE-AN遗传学研究.
结论:
- 不一致的SE-AN识别阻碍了识别遗传风险位置.
- 这种差距限制了对AN的新型治疗方法的开发.
- 为了推进AN遗传学研究,需要对SE-AN进行标准化的纳入标准.
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