怀孕期间多种微量营养素补充剂的坚持和可接受性:柬埔寨的一个集群随机非劣势试验的研究协议
Mai-Anh Hoang1, Hou Kroeun2, Rolf Klemm3,4
1Helen Keller Intl, Asia Pacific, Manila, Philippines.
Trials
|April 29, 2024
概括
这项研究比较了柬埔寨孕妇对多种微量营养素补充剂 (MMS) 和铁和叶酸 (IFA) 的坚持. 结果将指导MMS的全国扩展,以改善母亲和婴儿健康.
科学领域:
- 母婴健康 孕产妇和婴儿健康
- 营养补充 营养补充 营养补充
- 公共卫生实施实施.
背景情况:
- 柬埔寨目前为孕妇提供铁和叶酸补充剂 (IFA).
- 新出现的证据表明,多重微量营养素补充剂 (MMS) 对围产和婴儿健康的益处比单独的IFA更大.
- 实施研究对于指导柬埔寨拟议的从IFA向MMS的过渡至关重要,重点是可接受性和遵守性.
研究的目的:
- 评估在柬埔寨产前护理期间的MMS与IFA相比,MMS的坚持性和可接受性.
- 提供数据,以告知卫生部拟议的从IFA向MMS的过渡.
- 引导MMS在国家和全球范围内有效和可行的扩大规模.
主要方法:
- 一个非劣势试验,涉及柬埔寨48个卫生中心的1545名孕妇.
- 三个臂:90天的IFA (IFA-90),180天的MMS (两个90计数瓶,MMS-90),或180天的MMS (一个180计数瓶,MMS-180).
- 主要结果:MMS-180与IFA-90的坚持率 (药片计数) 没有劣势,保证了15%的差距. 通过对30,90和180天的调查来衡量可接受性.
主要成果:
- 对于MMS-180的坚持率将与IFA-90进行比较,以确定非劣势性.
- IFA和MMS的可接受性将在多个时间点进行定量评估.
- 使用混合效应物流和线性回归模型进行统计分析.
结论:
- 研究结果将为柬埔寨扩大MMS的战略提供信息.
- 结果将在全球范围内分享,以帮助其他国家规划MMS扩展.
- 这项研究支持基于证据的政策,以改善母婴营养.
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