饮食炎症对肥胖与瘦身个体NAFLD发展的影响:基于NHANES 2003-2018的分析
Lurao Li1,2, Xiawen Shu1,2, Yun Yi1,2
1Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.
Lipids in health and disease
|April 29, 2024
概括
通过饮食炎症指数 (DII) 测量的促炎症饮食与一般人群中非酒精性脂肪肝疾病 (NAFLD) 有关. 这种关联在肥胖个体中比瘦的个体更强.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 影响肥胖和正常体重的个体,称为"瘦 NAFLD".
- 对瘦肉性NAFLD的饮食影响尚不清楚.
- 本研究研究了饮食炎症指数 (DII) 和NAFLD之间的关系,考虑了体重指数 (BMI) 和腰与身高比 (WHtR).
研究的目的:
- 调查美国人口中饮食炎症指数 (DII) 和NAFLD之间的相关性.
- 根据BMI和WHtR来分层这个协会.
- 为了探索饮食对瘦身NAFLD的影响.
主要方法:
- 分析了来自2003-2018年国家健康和营养检查调查 (NHANES) 的5152名参与者.
- 使用血清学标志物诊断的NAFLD和晚期肝纤维化.
- 饮食炎症指数 (DII) 根据28个食物参数计算;根据BMI和WHtR确定瘦身和腹部瘦身状态.
主要成果:
- 在DII和NAFLD (OR=1.81) 和晚期肝纤维化 (OR=1.46) 之间发现了正相关性.
- 这一关联在肥胖 (BMI ≥25.00 kg/m2) 和腹部肥胖 (WHtR >0.50) 个体中显著.
- 与肥胖人群相比,瘦人群中DII和NAFLD之间的联系不那么明显.
结论:
- 一种由较高的DII分数表明的促炎症饮食,在一般人群中与NAFLD有显著的关联.
- 饮食炎症对NAFLD的影响在肥胖或腹部肥胖的人群中更为明显.
- 针对炎症的饮食干预措施可能对管理NAFLD至关重要,特别是在风险人群中.
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