母亲抑郁症症状与儿童端粒长度之间的关联
Caroline G Walker1, Zaneta M Thayer2, Emma J Marks1
1Centre for Longitudinal Research - He Ara ki Mua and Growing Up in New Zealand, University of Auckland, New Zealand.
Journal of psychiatric research
|April 30, 2024
概括
怀孕期间和之后的孕产妇抑郁症与儿童的端粒长度延长有关. 这一意想不到的发现表明端粒长度可能是对早期生活压力的适应性反应,而不是加速衰老.
科学领域:
- 发展心理学 发展心理学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 生命早期的不良事件通过不太了解的生物机制影响成人疾病风险.
- 由端粒长度表示的加速生物衰老是将早期压力与以后的疾病联系起来的途径.
- 母亲抑郁症与儿童端粒长度之间的联系需要进一步研究.
研究的目的:
- 为了检查母亲抑郁症 (产前和产后) 和4岁儿童端粒长度之间的关系.
- 探索潜在的生物机制,如端粒长度,将早期生活中的逆境与长期健康结果联系起来.
- 调查母亲抑郁是否影响孩子的端粒长度,这是生物衰老的生物标志物.
主要方法:
- 研究了4299名儿童的队列.
- 在怀孕期间和分娩后9个月和54个月使用验证的问卷 (爱丁堡抑郁量表,患者健康问卷9) 评估母亲抑郁症.
- 用唾液的DNA测量儿童端粒长度,回归分析控制了诸如母亲年龄,儿童性别,种族,妊娠年龄和农村地区等共变量.
主要成果:
- 母亲在产后9个月和54个月报告抑郁症得分较高的儿童的端粒长度显着更长.
- 具体来说,在9个月 (系数0.003,P=0.01) 和54个月 (系数0.003,P=0.02) 的母亲抑郁症得分较高,与儿童端粒长度增加有关.
- 这些发现被调整为回归模型中的潜在混因素.
结论:
- 这项研究发现,母亲产后抑郁症与儿童端粒长度之间存在矛盾的正相关性.
- 增长的端粒长度可能代表适应性生物反应,以早期的生活压力,而不是加速衰老.
- 需要进一步的研究来阐明这种关联背后的机制,并确定它是否是一种发育适应或间接的环境后果.
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