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巨细胞衍生的人类抵抗素在实验性炎症性关节炎中促进周围血管脂肪组织功能障碍

Aline G Fedoce¹, Flávio P Veras¹, Marcos H Rosa¹

¹Center of Research in Inflammatory Diseases (CRID), University of Sao Paulo, Ribeirao Preto, SP, Brazil; Department of Pharmacology, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Biochemical pharmacology

|April 30, 2024

概括

巨细胞衍生的抵抗素驱动周血管脂肪组织 (PVAT) 炎症和功能障碍,导致类风湿性关节炎 (RA) 中的心血管疾病 (CVD). 向抵抗素可能会减少与RA相关的血管并发症.

科学领域:

免疫学免疫学免疫学
心脏病学心脏病学
内分泌学在内分泌学.

背景情况:

类风湿性关节炎 (RA) 显著增加了心血管疾病 (CVD) 的风险.
抵抗素是一种阿迪波金,涉及脂肪组织炎症和单细胞/巨细胞激活.
在RA中抗原的升高可能导致周血管脂肪组织 (PVAT) 功能障碍和血管损伤.

研究的目的:

研究抗原诱导性关节炎 (AIA) 中促进PVAT功能障碍中的抵抗素的作用.
评估在AIA期间PVAT内对巨细胞透和炎症性细胞因子的影响.

主要方法:

使用野生类型,抵抗性淘汰 (RTN-/-) 和人性化抵抗性 (hRTN+/-) 鼠标与AIA.
评估了AIA疾病活性,PVAT功能,细胞性和分子标记.
在抵抗剂暴露后对动脉功能进行了体外研究.

主要成果:

在WT和hRTN+/-AIA小鼠的PVAT和血中,抵抗剂水平升高.
通过减少PVAT的抗收缩作用,体外对抗素的暴露损害了血管功能.
在WT和hRTN+/-AIA小鼠中观察到PVAT功能障碍;resistin knockdown阻止了这一点.
大细胞衍生细胞因子,M1/M2标记物和CAP1表达在hRTN+/-AIA PVAT中增加,但在RTN-/-小鼠中没有增加.

结论:

巨细胞衍生的抵抗素促进PVAT炎症和功能障碍,而不依赖于AIA疾病的严重程度.
抗素成为缓解RA患者血管功能障碍和心血管疾病的潜在治疗标.

关键词:

细胞因子 (cytokines) 是一种细胞因子.巨细胞是一个巨细胞.这是PVAT的PVAT.没有抵抗力.类风湿性关节炎类风湿性关节炎类风湿性关节炎血管功能障碍血管功能障碍

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