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一个正式的造血细胞移植幸存计划的结果在查晚期影响

Richard A Newcomb¹, Lucy Gao¹, Julie Vanderklish¹

¹Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

Transplantation and cellular therapy

|April 30, 2024

概括

正式的造血细胞移植 (HCT) 生存计划显著改善了对移植后并发症的查依从性. 这些计划增强了患者的随访护理和HCT幸存者的长期健康结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
移植医学移植医学

背景情况:

异质造血细胞移植 (HCT) 幸存者需要持续监测潜在的长期并发症.
结构化幸存者计划在确保遵守推查方案方面的有效性仍然是研究领域.

研究的目的:

评估正式的学术HCT幸存者计划对查对移植后并发症的坚持的影响.
为了比较不同时期的查遵守率,包括在生存计划实施之前和之后.

主要方法:

对接受异构HCT并在HCT后1年活着且没有复发的患者的回顾性分析.
测量了对心血管,肺,眼睛,二次癌症和内分泌评估的查坚持.
使用多变量后勤和Cox比例危险回归分析来比较三个时间段的查遵守情况:前生存期 (2012-2014) 和两个后生存期 (2016-2018,2019-2021).

主要成果:

查坚持显著增加在后生存期 (47.7%在2016-2018年和34.7%在2019-2021年) 与前生存期 (16.9%) 相比.
完成正式HCT生存咨询的患者更有可能遵守查指南.
幸存者计划对及时完成评估产生了积极影响,在幸存者后期完成所有查的显着增加.

结论:

一个正式的HCT幸存者计划,包括初级和专业护理组件,有效地提高了HCT幸存者的查遵守率.
这些发现支持整合结构化的幸存者计划,以改善HCT接受者的长期护理和监测.
需要进一步的研究来评估这些计划的更广泛的有效性,传播和实施策略.

关键词:

全原性血液细胞移植细胞移植.骨的健康骨的健康心血管健康的心血管健康在GVHD中,GVHD是指GVHD.检查检查检查检查检查检查检查检查检查幸存者的生存方式

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