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纤维凝的微拉伸性质学量化了取决于菌株的异构性
Shahar Goren1, Bar Ergaz2, Daniel Barak3
1School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Israel; School of Mechanical Engineering, the Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Israel; Center for Physics and Chemistry of Living Systems, Tel Aviv University, Israel.
Acta biomaterialia
|April 30, 2024
概括
像原蛋白和纤维素这样的细胞外基质凝在微小的变形下显著硬,形成异质性. 这种微观应变强化对于理解组织发育和疾病至关重要.
科学领域:
- 生物物理学的生物物理.
- 生物材料科学 生物材料科学
- 细胞力学 细胞力学
背景情况:
- 半柔性纤维凝 (例如,原蛋白,纤维素) 呈现出对组织过程至关重要的非线性力学.
- 光学 tweezers 微观神经学已经对纤维凝力学 (异质性,异构性) 的理解有所进步.
- 微机械性质和凝变形之间的联系在很大程度上仍未得到量化.
研究的目的:
- 调查纤维素和原凝中微观应变和硬化之间的关系.
- 为了量化对凝变形的反应中异性质的发展.
- 为了比较变形诱导的硬化与癌细胞重塑矩阵中发现的变形诱导的硬化.
主要方法:
- 开发了一种新的凝拉伸装置.
- 同时使用光学子进行微观学测量.
- 伸展凝高达15%并测量微观的异构硬度.
主要成果:
- 凝在~10%的变形时表现出显著的硬化 (平行与垂直于拉伸轴的两到三倍硬).
- 随着压力增加,观察到中度异性质的出现.
- 在癌细胞重塑矩阵中发现了类似的硬化和异质性模式.
结论:
- 细胞外微环境对变形非常敏感,小菌株会诱导大量的硬化和异质性.
- 这些发现对组织平衡,形态发生和癌症转移有影响.
- 这项研究量化了微观变形,导致纤维凝的应变硬化和异构性.
关键词:
没有异性otropy.原蛋白是一种原蛋白.变形变形是因为变形.细胞外矩阵是一个细胞外矩阵.纤维的对齐方式纤维素纤维素是一种纤维素.微观地质学的微观地质学光学子是一种光学子.瘤微环境是一个微环境.更多相关视频
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