心房动与心力衰竭之间的关联患者报告了整个射出分数谱的结果
Khaled Elkholey1, Zain Ul Abideen Asad2, Esraa Shehata3
1Department of Medicine, Centennial Medical Center, Nashville, TN.
American heart journal
|April 30, 2024
概括
心房动 (AF) 在心力衰竭 (HF) 患者中显著恶化与健康相关的生活质量 (HRQoL). 这种影响在保留喷射率 (HFpEF) 和减少喷射率 (HFrEF) 的HF类型中观察到.
科学领域:
- 心脏病学 心脏病学
- 临床研究 临床研究
- 生活质量研究 生命质量研究
背景情况:
- 心房动 (AF) 是心力衰竭 (HF) 患者常见的并发症.
- AF存在与高频率患者的临床结果较差有关.
- 在HFpEF和HFrEF中,AF对纵向健康相关生活质量 (HRQoL) 的影响尚未完全理解.
研究的目的:
- 评估AF与HRQoL变化之间的关系.
- 为了评估HRQoL使用堪萨斯城心肌病问卷 (KCCQ) 在HF患者和没有AF.
- 分析这些影响,无论是保持射出分数 (HFpEF) 的HF还是减少射出分数 (HFrEF) 的HF种群.
主要方法:
- 对TOPCAT和HF-ACTION试验的后期分析.
- 混合效应回归模型被用来检查AF对KCCQ总体总结分数 (OSS) 的影响.
- 患者被分为三个组:AF史 (Hx AF),入学时ECG检测到的AF (ECG AF) 和随机化后新发的AF (新AF).
主要成果:
- 在TOPCAT试验中,AF与48个月后KCCQ-OSS显著下降有关 (差异: -3.98).
- 在HF-ACTION试验中,AF与24个月后KCCQ-OSS显著下降有关 (差异: -3.67).
- 在这两项试验中,AF类型和KCCQ-OSS变化之间没有发现显著的关联.
结论:
- 在患有HFpEF和HFrEF的患者中,心房动与更糟糕的HRQoL独立相关.
- KCCQ是测量HF患者的HRQoL下降的一个有价值的工具.
- 在心力衰竭管理中,管理AF可能对改善生活质量至关重要.
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