来自Alpinia officinarum根茎的具有神经保护作用的二甲基胺类药物
Liping Mu1, Ji Wang1, Tang Zhou1
1School of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, PR China.
Fitoterapia
|April 30, 2024
概括
阿尔皮尼亚 (Alpinia officinarum) 的根茎含有具有显著神经保护作用的二甲基胺. 几个化合物保护神经元细胞的氧化应激,表明治疗潜力.
科学领域:
- 植物化学 植物化学
- 神经药理学神经药理学
- 自然产品 化学 化学
背景情况:
- 阿尔皮尼亚 (Alpinia officinarum) 是一种传统的药用植物.
- 烯类化合物是一种具有多种生物活性的自然化合物.
- 氧化应激与各种神经退行性疾病有关.
研究的目的:
- 从Alpinia officinarum根茎中分离和特征化二甲类植物.
- 评估隔离化合物对SH-SY5Y细胞中过氧化 (H2O2) 诱导的氧化应激的神经保护作用.
- 确定负责神经保护的特定化合物和机制.
主要方法:
- 使用光谱技术 (UV,IR,HRESIMS,NMR) 隔离和阐明43种二甲基类的结构.
- 在体外神经保护测定使用H2O2受损的SH-SY5Y神经母细胞瘤细胞.
- 评估反应性氧物种 (ROS) 含量,甲 (MDA) 和氧化 (NO) 的产生.
主要成果:
- 在43种分离的化合物中,发现了8种新的二甲基类化合物.
- 十一种化合物 (7,10,12,20,22,25,28,33,35,37,42) 与甲基甲酸盐 (EGCG) 相比表现出显著的神经保护作用.
- 化合物10,22,25和33在氧化损伤细胞中显示出强大降低ROS,MDA和NO水平.
结论:
- 阿尔皮尼亚 (Alpinia officinarum) 的根茎是一种丰富的神经保护性二甲类药物的来源.
- 特定的二甲基类药物具有显著的潜力,可以减轻氧化应激诱导的神经元损伤.
- 这些发现支持Alpinia officinarum的民族药理学用途,并为开发新型神经保护剂奠定了基础.
相关概念视频
01:22Alzheimer's Disease: Treatment
183
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
183
01:24Parkinson's Disease: Treatment
264
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
264
01:57Preparation of Diols and Pinacol Rearrangement
3.4K
Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
3.4K