来自Eugenia caryophyllata的抗炎纳夫托基诺-单烯添加物和新木质物
Xue-Yi Li1, Jun Jiang1, Beiyi Shu1
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong-Hong Kong-Macau Join Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China; Center for Bioactive Natural Molecules and Innovative Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
发现了来自Eugenia carvophyllata的七种新化合物. 一些化合物表现出抑制细胞中呼吸道同胞性病毒 (RSV) 诱导的氧化生产的活性.
科学领域:
- 植物化学 植物化学
- 自然产品化学 自然产品化学
- 药用植物研究 药用植物研究
背景情况:
- 欧尼亚卡尔沃菲拉塔 (Eugenia carvophyllata) 是一种食用药用植物.
- 植物化学研究旨在发现新的生物活性化合物.
研究的目的:
- 从Eugenia carvophyllata芽中分离和描述新的化学化合物.
- 评估分离化合物的生物活性.
主要方法:
- 使用光谱分析 (NMR,MS) 的植物化学调查.
- 用于结构确定的X射线衍射晶体学.
- 量子化学计算用于结构验证.
- 试验室试验评估RAW264.7细胞中呼吸道同胞病毒 (RSV) 诱导的氧化 (NO) 生产的抑制活性.
主要成果:
- 发现了七种新的化合物,卡里奥A-G (1-7).
- 化合物1-3是新型纳夫托基-单烯附加物,具有新的碳骨架.
- 化合物4-7是具有不寻常的链接模式的新新.
- 化合物 (-) -2,3,6和9在体外对RSV诱导的NO产生表现出显著的抑制作用.
结论:
- 尤金尼亚 carvophyllata 的芽是新型植物化学物质的来源.
- 新发现的化合物具有独特的化学结构.
- 一些孤立的化合物显示出对RSV感染的潜在治疗价值.
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