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聚氧甲酸对人类呼吸道病毒具有广泛的活性,阻碍病毒进入

Irene Arduino¹, Rachele Francese¹, Andrea Civra¹

¹Department of Clinical and Biological Sciences, Laboratory of Molecular Virology and Antiviral Research, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.

Antiviral research

|April 30, 2024

概括

两种新型聚氧甲酸盐对人类呼吸道病毒具有广泛的抗病毒活性. 一种化合物Ti2PW10有效地抑制病毒的进入,并且具有很高的抗药性障碍,这表明潜在的新疗法.

科学领域:

病毒学和抗病毒药物发现.
材料科学,特别是聚氧甲酸盐 (POM).

背景情况:

人类呼吸道病毒对全球健康和经济造成重大负担.
现有的抗病毒治疗方法有限,需要新的治疗策略.
聚氧甲酸盐 (POMs) 是具有多种应用的无机化合物,包括潜在的生物活性.

研究的目的:

识别和描述具有针对人类呼吸道病毒的广泛抗病毒活性的POMs.
评估有希望的POM候选者的抗病毒疗效,作用机制和耐药性.
评估抗病毒POM的生物相容性和治疗配方潜力.

主要方法:

对两种Keggin类型的POMs,即[TiW11CoO40]8- (TiW11Co) 和[Ti2PW10O40]7- (Ti2PW10) 的查,针对一组人类呼吸道病毒 (HCoV-OC43,HRV-A1,RSV-A2,AdV-5) 的小组.
选择性指数 (SIs) 的确定和作用机制的调查 (病毒结合,进入,复制).
通过序列传递评估耐药性的发展,并通过人类鼻上表皮的3D模型评估疗效,并进行细胞毒性测试.
开发一种粘粘性热敏 in situ 水凝配方,用于鼻腔输送.

主要成果:

TiW11Co和Ti2PW10都显示出广泛的抗病毒活性.
Ti2PW10表现出高选择性指数 (SIs>700),并有效抑制了多个人类冠状病毒 (HCoV) 和人类犀牛病毒 (HRV) 菌株的复制.
Ti2PW10可以选择性地阻止病毒的进入,而不会影响病毒的结合或细胞内复制,病毒对发展抗性的障碍很高.
在3D鼻腔模型中,Ti2PW10降低了HRV-A1的产生,但没有引起细胞毒性或组织损伤;成功开发了一种鼻腔输送配方.

结论:

POM Ti2PW10显示了针对人类呼吸道病毒的显著广泛的抗病毒潜力.
它的抑制病毒进入的机制,高生物相容性和对抗性发展的低倾向使其成为治疗急性呼吸道病毒感染的有希望的候选人.
需要进一步的研究来阐明精确的分子标,并评估Ti2PW10.10的临床实用性.

关键词:

抗病毒剂是一种抗病毒剂.进入抑制剂进入抑制剂聚氧甲酸盐是一种多氧金属酸盐.电阻电阻电阻电阻电阻电阻呼吸道感染呼吸道感染

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