根据美国乳腺癌幸存者的种族和种族,第二次原发性癌症风险在美国乳腺癌幸存者中不同
Carolyn Brandt1, Jacqueline B Vo1, Gretchen L Gierach1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
International journal of cancer
|April 30, 2024
概括
乳腺癌幸存者面临的第二种癌症的风险更高,在种族和民族群体中观察到显著的差异. 这些发现凸显了针对性干预的必要性,以解决癌症护理中的这些不平等问题.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 健康差异 在健康上的差异
背景情况:
- 乳腺癌幸存者患上后续原发性癌症的风险较高.
- 现有的研究还没有全面详细介绍这些风险在不同的种族和族裔群体.
- 理解这些差异对于公平的癌症幸存者护理至关重要.
研究的目的:
- 评估和比较乳腺癌幸存者之间的第二次原发性癌症风险,跨越不同种族和种族群体.
- 确定特定的幸存者的小组,特别高于随后癌症的风险.
- 调查乳腺癌指数特征对第二种癌症风险的影响,按种族和民族分类.
主要方法:
- 利用了SEER注册表中717,335名被诊断为原发性乳腺癌的妇女的数据.
- 计算的标准化发病率 (SIRs),将幸存者的风险与一般人口进行比较,按种族和种族分层.
- 采用波桑回归来分析风险的异质性,并检查了与诊断时的年龄和瘤受体状态等临床因素的关联.
主要成果:
- 在第二种癌症风险中观察到显著的种族和种族差异,与白人幸存者相比,亚裔美国人,夏威夷原住民或其他太平洋岛民 (AANHPI),黑人和西班牙裔/拉丁裔幸存者的SIRs更高.
- 在AANHPI,黑人和拉丁裔幸存者中,风险增加尤为明显,这些幸存者在50岁之前被诊断出患有雌激素受体阴性瘤或雌激素受体阴性瘤.
- 在AANHPI,黑人和拉丁裔幸存者中,明显增加了特定癌症的风险,包括白血病,逆侧乳腺癌和唾液腺癌.
结论:
- 在乳腺癌诊断后患第二种原发性癌症的风险存在明显的种族和民族差异.
- 诊断时年轻的年龄和雌激素受体阴性状态与少数幸存者群体中较高的第二癌症风险有关.
- 进一步的研究是必不可少的,以制定有针对性的早期检测和治疗策略,以减轻这些癌症结果差异.
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