血栓等度测试用于评估42只自然发生热中风的狗的血液静止和疾病严重程度
Michal Yanai1, Sigal Klainbart1, Gal Dafna1
1The Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, Israel.
Journal of veterinary internal medicine
|April 30, 2024
概括
血小板造影 (TEM) 可以预测热中风的狗的结果. 经TEM表示的低凝血性与更差的预后和诸如损伤和DIC等并发症有关.
科学领域:
- 兽医内科 兽医内科
- 凝血科学 凝血科学
- 关键护理医学 关键护理医学
背景情况:
- 血栓形成显微镜 (TEM) 提供了对凝血级联的全面分析.
- 以前的研究还没有评估TEM在狗热中风引起的凝血病的效用.
研究的目的:
- 评估热中风的狗中TEM的诊断和预后价值.
- 调查TEM参数与狗热中风结果之间的关系.
主要方法:
- 一项前性观察性研究涉及42只被诊断患有热中风的客户拥有的狗.
- 血液样本在呈现时使用内在 (INTEM) 和外在 (EXTEM) TEM进行分析,并在每12-24小时进行一次,持续48小时.
- 凝血状态 (低,正常或高凝血) 取决于TEM在第一个导数曲线 (AUC) 下的面积.
主要成果:
- 病例死亡率为31%. 一些TEM变量,包括INTEM凝血时间和AUC,与死亡率有显著的关联.
- 大多数狗呈现为正常凝固,但在呈现后12-24小时变得低凝固.
- 低凝血INTEM表型在非幸存者中更为普遍,并且与急性损伤 (AKI) 和传播性血管内凝血 (DIC) 的发病率增加有关.
结论:
- 通过INTEM AUC测量的低凝血率作为狗热中风预后不佳的重要预测因素.
- TEM的发现可以帮助识别患二次并发症风险较高的狗,包括AKI和DIC.
- TEM提供了有关热中风期间凝血动态的宝贵见解,有助于风险分层和临床管理.
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