马格诺利亚·比昂迪 (Magnolia biondii) 花提取物通过高流动性组盒子蛋白B1减轻UVB诱导的皮肤损伤
Fang Huang1, Qing Liu1, Yina Lu1
1Technology Innovation Center, JAKA Biotech. Co., Ltd., Shanghai, China.
International journal of cosmetic science
|April 30, 2024
概括
马格诺利亚生物花提取物 (MB) 有效地减少UVB诱导的皮肤损伤,改善组织活力和减少炎症. 这种天然化合物通过影响细胞损伤通路来缓解红和色素.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 马格诺利亚生物 (MB) 含有类似马格诺利亚的化合物,具有已知的抗炎和抗过敏特性.
- 以前的研究还没有研究MB在减轻紫外线 (UV) 引起的皮肤损伤方面的有效性.
研究的目的:
- 调查M. biondii花提取物 (MB) 对UVB诱导的皮肤损伤的保护作用.
- 探索细胞损伤和与损伤相关的分子模式 (DAMP) 之间的关系,在UVB暴露的皮肤中使用MB.
主要方法:
- 利用重建的表皮模型和人类前皮样本来评估细胞对UVB辐射和MB治疗的反应.
- 采用MTT测定,H&E染色和免疫光检测来评估细胞活力,晒伤细胞和DAMP的表达/迁移.
- 通过ELISA测量了前列腺素E2 (PGE-2) 和中白素8 (IL-8) 的水平.
- 通过皮肤探针和VISIA成像,在人手臂上进行了临床试验,以评估MB对红血,黑色素,ITA°和跨皮肤水分流失 (TEWL) 的影响.
主要成果:
- 富含基素的MB在UVB照射模型中显示改善了组织活力和结构.
- MB治疗显著降低了高流动性组盒蛋白B1 (HMGB1) 的表达和迁移,以及IL-8和PGE-2水平.
- 在临床研究中,MB治疗前后减轻了UVB诱导的红血,色素和皮肤间的水分流失,同时改善了皮肤ITA°.
结论:
- M. biondii花取物 (MB) 有效地减轻UVB诱导的皮肤损伤,包括红斑,色素和皮肤屏障功能受损.
- MB增强组织活力和结构,减少晒伤细胞,减轻皮肤炎症.
- MB的保护作用可能与其减少DNA损伤和随后的HMGB1迁移的能力有关,从而抑制炎症.
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