在有认知问题的老年患者中使用抗胆固醇和镇静药物
Caroline E Hinkle1,2, Jennifer D Davis1,3, Idania Arias3
1Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Journal of the American Geriatrics Society
|April 30, 2024
概括
抗胆固醇 (AC) 和镇静药物在接受神经心理评估的老年人中很常见. 镇静剂的使用与注意力/处理速度 (AP) 和执行功能 (EF) 的降低有关,而AC负担与AP缺陷有关.
科学领域:
- 老年学是指老年学的学科.
- 临床神经心理学 临床神经心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗胆固醇 (AC) 和镇静药物是老年人认知障碍的已知的危险因素.
- 了解这些药物的患病率和影响对于神经心理学评估至关重要.
研究的目的:
- 描述在接受神经心理评估的老年门诊患者中使用AC和镇静药物的情况.
- 评估AC和镇静剂使用与特定认知领域之间的关联,包括注意力/处理速度 (AP),执行功能 (EF) 和记忆.
主要方法:
- 对392名老年患者 (平均年龄72岁) 进行了横截面图表审查.
- 药物被评估为AC使用 (抗胆固醇认知负担量表 (ACB) 评分≥1),镇静剂使用和多药性 (每天≥5种药物).
- 对AP,EF和记忆的人口调整认知复合物被使用两变相关性和多变线性回归分析.
主要成果:
- 多药性是普遍存在的 (80%),安静剂使用 (70%) 和AC药物使用 (63%) 也是如此.
- 镇静剂的使用显示了与AP (r=-0.134,p=0.008) 和EF (r=-0.105,p=0.04) 的负相关性.
- ACB分数与AP负相关 (r=-0.106,p=0.037),而镇静剂使用独特地预测了更差的AP性能 (β=-0.426,p=0.049). 没有发现与记忆的显著关联.
结论:
- 抗胆固醇和镇静药物,以及多药,在老年门诊患者中很常见.
- 镇静剂使用与注意力/处理速度 (AP) 有显著的负面关联,AC负担与AP缺陷有关.
- 虽然记忆没有直接关联,但AP和EF的缺陷可能会表现为记忆问题,特别是考虑到本样本的抗胆固醇负担总体较低.
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