肝脏肥胖症在患有输血依赖性沙拉塞米亚的患者中
Paolo Ricchi1, Laura Pistoia2,3, Vincenzo Positano3,4
1Unità Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", Napoli, Italy.
British journal of haematology
|April 30, 2024
概括
肝硬化症在输血依赖的血病患者中很常见,与铁过载,体重增加和C型肝炎有关. 它还增加了异常葡萄糖代谢的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 血液学 血液学 血液学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 输血依赖性沙拉西米亚 (TDT) 患者经常因慢性输血而发展并发症.
- 肝硬化 (LS) 是一种潜在的并发症,但其在TDT中的患病率和临床关联尚未完全理解.
研究的目的:
- 评估TDT患者肝肥胖症的患病率和临床关联.
- 确定LS的决定因素及其与葡萄糖代谢和心脏功能的关系.
主要方法:
- 磁共振成像 (MRI) 用于评估肝脏脂肪分数 (FF) 和铁过载 (T2*技术).
- 用电影MRI评估心脏功能,通过口服葡萄糖耐受性测试 (OGTT) 评估葡萄糖代谢.
- 包括301名TDT患者和25名健康人群.
主要成果:
- 与健康人 (0.55%) 相比,TDT患者的肝脏FF显著更高 (1.48%).
- 36.4%的TDT患者患有LS (FF>3.7%). 在TDT患者中,有36.4%的TDT患者患有LS (FF>3.7%).
- LS的独立决定因素包括活跃的C型肝炎病毒 (HCV) 感染,体重指数增加和肝脏铁. 肝脏FF>3.53%预测异常的OGTT.
结论:
- 肝硬化是TDT患者经常发现的病例.
- LS与铁过载,体重增加,HCV感染有关,并预测葡萄糖代谢变化的风险增加.
- 在TDT患者中,LS可能会影响左心室质量指数.
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