长期的SARS-CoV-2感染中的放射性异常:系统性审查
Kyongmin Sarah Beck1, Jeong-Hwa Yoon2, Soon Ho Yoon3
1Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Korean journal of radiology
|April 30, 2024
概括
长期冠状病毒病19 (COVID-19) 在免疫功能低下的患者中经常在CT扫描上显示迁移性肺炎. 这一发现在B细胞缺乏症患者中尤为明显,表明随着时间的推移,有明显的放射性模式.
科学领域:
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 长期的SARS-CoV-2感染,定义为超过21天的阳性PCR,持续或复发的症状,影响免疫力低下的人.
- 患有潜在淋巴瘤的患者和接受抗CD20治疗的患者特别容易发生长期感染.
研究的目的:
- 系统地审查和分析长期感染SARS-CoV-2的患者CT扫描上的放射性异常.
- 描述CT检测结果的模式,分布和随着时间的推移在这个患者队列中的演变.
主要方法:
- 对24名长期感染SARS-CoV-2的患者进行系统性文献综述.
- 基于时间相对于初始PCR阳性的CT图像的分析.
- 评估CT发现,肺部参与严重性得分,以及病变迁移的存在.
主要成果:
- 大多数患者在CT上呈现出典型的COVID-19肺炎 (地面玻璃不透明,整合).
- CT严重性得分在≤21天显著降低,而在>21天 (P<0.001) 显著降低.
- 在CT上损伤迁移显著增加,从≤21天 (22.7%) 增加到>21天 (68.2%-87.5%).
结论:
- 在免疫功能低下的患者中,长期的SARS-CoV-2感染通常表现为迁移COVID-19肺炎.
- 观察到的放射性变化,特别是迁移,在感染过程中演变.
- 损坏的B细胞免疫力是与长期的SARS-CoV-2感染及其特征性CT发现相关的关键因素.
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