在接受激进切除术的男性中,阴性腺缺陷,虚弱和术后后果
Daniel R Greenberg1, Stephen P Rhodes2, Alon Lazarovich3
1Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Journal of surgical oncology
|April 30, 2024
概括
在接受激进切除术的男性中,低腺症和脆弱性很常见,并且与术后并发症的增加有关. 在这项研究中,替代疗法对结果没有显著影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 老年医学 老年医学
背景情况:
- 双胞胎缺血症和脆弱性是进行激进切除术 (RN) 的男性不良结果的潜在危险因素.
- 评估性腺缺陷的患病率及其与脆弱性和术后结果的关联对于手术风险分层至关重要.
研究的目的:
- 为了确定在接受RN的男性中阴性腺的患病率.
- 为了研究阴性双胞胎缺陷,虚弱和术后不良结果之间的关联.
主要方法:
- 对接受RN的男性进行IBM Marketscan数据库 (2012-2021) 的回顾性分析.
- 使用医院脆弱性风险评分 (HFRS) 评估的虚弱性; 催眠症定义为在RN之前5年内诊断.
- 对术后结果的评估,包括停留时间,并发症,急诊室访问和再接收;对替代疗法 (TRT) 影响的亚组分析.
主要成果:
- 在接受RN的13,598名男性中,7.1%的人患有阴道腺缺陷症.
- 患有阴性腺体缺陷症的男性表现出较高的虚弱度得分,以及手术后骨髓,急性损伤和心脏骤停的发病率增加.
- 高风险的虚弱与90天的急诊室访问和再入院的增加显著相关;TRT与术后结果没有关联.
结论:
- 阴性腺缺陷和虚弱是进行激进切除术的男性手术后不良后果的重要危险因素.
- 在手术前的评估中,应考虑阴性双胞胎缺陷和脆弱性,以进行全面的风险评估.
- 进一步的研究可能会探索在这个患者群体中治疗阴道腺的最佳管理策略.
相关概念视频
01:20Disorders of the Male Reproductive System
400
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
400
01:28Menopause
156
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
156
01:23Infertility in Males
260
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
260
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:17Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
01:41Spermatogenesis
102.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.4K