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在不孕男性中,随着时间的推移,精子参数和总运动细胞数的个体内变化

Gilad Karavani¹, Bader Akroof¹, Susan Lau¹

¹Department of Surgery, Division of Urology, Mount Sinai Hospital, University of Toronto, Toronto, Canada.

|April 30, 2024

概括

不育男性的精液参数通常随着时间的推移而下降,在3-5年后观察到总运动细胞数 (TMC) 的显著下降. 这种下降会影响生育潜力,可能需要进行诸如体外受精/细胞内质精子注射等干预措施.

科学领域:

生殖医学生殖医学
安德罗学与人类学
人类生育能力研究研究人类生育能力

背景情况:

父亲的年龄与精液体积,运动性和形态的减少有关,但不是度.
关于随着时间的推移,精液参数的个体长期变化存在有限的数据.

研究的目的:

为了评估随着时间的推移,不孕男性的精液参数和总运动细胞计数 (TMC) 的个体内变化.
确定影响TMC下降的因素.

主要方法:

2018年不孕男性的回顾性队列研究,在2005-2021年期间至少进行了两次精液分析.
根据分析之间的时间间隔,男性被分组为3-12个月,1-3年,3-5年和>5年.
主要结局:精子参数的变化;次要结局:从初始TMC (>100万) 到TMC (<500万) 的下降.

主要成果:

精子度在前3年增加,而体积,运动性和形态学保持稳定.
精液参数 (体积,运动性,形态) 在>5年后显著下降.
随着时间的推移,总运动细胞数 (TMC) 显著下降 (p<0.001).
大约22%的初始TMC>1000万的男性在5年后下降到500万以下.
低TMC的预测因素包括较短的基线体积,较低的基线TMC和分析之间的较长时间间隔 (3-5年和>5年).

结论:

精液参数,特别是TMC,在不孕男性中长期 (>3年) 倾向于下降.
很大一部分男性经历TMC的下降,这可能会影响自然受孕的可能性.
研究结果支持个性化计划生育,关于怀孕时间的咨询,以及对不育男性进行精子储存的考虑.

关键词:

在子宫内进行授精.在体外受精受精在体外受精男人不孕不育的原因精子精子精子总的移动细胞数量.

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