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形态测量与放射学之间的比较:根据灰质物质检测正常的大脑衰老.

Yuting Yan1, Xiaodong He1, Yuyun Xu1

  • 1Center for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

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概括

放射学模型在诊断大脑衰老方面表现优于传统的基于声素的形态测量 (VBM) 和基于表面的形态测量 (SBM). 放射学提供了优越的性能和概括性,而VBM-SBM更适合解释性.

关键词:
灰色物质是一种灰色物质.磁共振成像技术的使用形态测量法 形态测量法 形态测量法这是正常的衰老过程.无线电学 (radiomics) 是一种无线电学.

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科学领域:

  • 神经图像分析是一种神经图像分析.
  • 大脑衰老研究研究
  • 医学成像生物标志物生物标志物

背景情况:

  • 基于Voxel的形态测量 (VBM) 和基于表面的形态测量 (SBM) 是已知的神经成像技术.
  • 放射学是神经图像分析的一个新兴领域.
  • 在诊断大脑衰老方面,VBM-SBM和放射学之间的直接性能比较是有限的.

研究的目的:

  • 开发和比较VBM-SBM和放射学模型,用于诊断认知正常个体的大脑衰老.
  • 评估这些神经成像方法的优点,弱点和关系.
  • 确定确定与年龄相关的大脑变化的最佳方法.

主要方法:

  • 967名认知正常的参与者被分为中年 (n=302) 和老年 (n=665) 组.
  • 使用来自ADNI,AIBL,NACC和PPMI数据库的数据进行VBM-SBM和放射学模型的训练和测试.
  • 后勤回归被用于模型构建,通过AUC,灵敏度,特异性和准确性来评估性能.

主要成果:

  • 与VBM-SBM模型相比,放射学模型在训练和多个外部测试数据集中表现出卓越的性能.
  • 在大多数测试组中,放射学模型的曲线下面面积 (AUC) 值始终高于VBM-SBM模型.
  • 在VBM-SBM参数和放射学特征之间发现了微弱的相关性,这表明了补充信息.

结论:

  • 放射学模型显示了更大的性能和概括能力来诊断大脑衰老.
  • 当优先考虑可解释性和直接临床应用时,VBM-SBM模型更适合.
  • 放射学在衰老研究中为先进的神经图像分析提供了一个有前途的途径.