怀孕期间使用抗精神病药物和儿童患特定神经发育障碍和学习困难的风险:一项跨国队列研究
Claudia Bruno1,2, Carolyn E Cesta3, Vidar Hjellvik2
1School of Population Health, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
EClinicalMedicine
|April 30, 2024
概括
产前暴露于抗精神病药物并没有增加儿童神经发育障碍或学习困难的风险. 这一发现支持孕妇管理心理健康状况的知情决策.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 神经发育儿科 神经发育儿科
- 药物监督 药物监督 药物监督
背景情况:
- 抗精神病药物经常被处方用于生育年龄的妇女和怀孕期间的精神疾病.
- 对于在产前接触这些药物的儿童,存在潜在的神经发育风险的担忧.
研究的目的:
- 评估在怀孕期间接触抗精神病药物的儿童中出现神经发育障碍和学习困难的风险.
- 为临床医生和孕妇提供基于证据的信息.
主要方法:
- 一个大规模的,基于人口的跨国队列研究,使用来自北欧国家的全国性注册数据 (2000-2020年).
- 用倾向分数加权的Cox比例危险回归和Poisson回归来分析风险.
- 结果包括智力,言语/语言和学习障碍,以及数学和语言艺术方面的学业表现不佳.
主要成果:
- 在超过213,000名儿童中,5.5%的儿童在产前接触过抗精神病药物.
- 对于神经发育障碍 (aHR 1.06) 或数学 (aRR 1.04) 或语言艺术 (aRR 1.00) 的学业表现不佳的复合结果,没有观察到增加的风险.
- 在所有灵敏度分析中,结果保持一致.
结论:
- 这项研究表明,在产前暴露于抗精神病药物后,神经发育障碍或学习困难的风险很小或没有增加.
- 这些发现可以帮助临床医生和妇女在怀孕期间管理精神疾病.
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