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在中国多发性骨髓瘤患者中研究博特佐米布诱导的外围神经病变的遗传变体研究

Yan Zhang1, Heyang Zhang1, Jing Wang1

  • 1Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

Oncology research
|April 30, 2024
PubMed
概括

在多发性骨髓瘤患者中,遗传因素会影响博特佐米布诱导的周围神经病变 (BIPN). 较低的MTHFR基因表达和更高的同类半氨酸水平与增加的BIPN风险有关.

关键词:
博尔特佐米比 (Bortezomib) 是一种药物.波尔特佐米布诱导的外周神经病变在MTHFR的基础上.多发性骨髓瘤是多发性骨髓瘤的一种.这是下一代测序.周围神经病变是一种神经病变.血清中的 Hcycy

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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