来自结直肠癌患者的舌头涂层微生物组的表征
Qubo Chen1, Xiaoting Huang2, Haiyan Zhang3
1State Key Laboratory of Dampness Syndrome of Chinese Medicine, Biological Resource Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China.
Journal of oral microbiology
|April 30, 2024
概括
舌头涂层微生物组分析可以帮助预测结直肠癌 (CRC). 在CRC患者和健康个体之间,舌头涂层中的特定细菌物种和通路不同,提供潜在的诊断生物标志物.
科学领域:
- 微生物组研究 微生物组研究
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 越来越多地研究了舌头涂层微生物群,以了解其在口腔和消化系统癌症中的作用.
- 舌头涂层微生物组与结直肠癌 (CRC) 之间的特定关系在很大程度上仍未被探索.
研究的目的:
- 为了研究在结直肠癌 (CRC) 患者的舌头涂层微生物组合.
- 探索舌头涂层微生物群作为CRC预测生物标志物的潜力.
- 确定与CRC相关的特定微生物物种和途径.
主要方法:
- 在30名CRC患者,30名结直肠多 (CP) 患者和30名健康对照 (HC) 患者的舌头涂层样本上使用了metagenomic猎枪测序.
- 使用随机森林模型验证了舌头涂层微生物群对CRC的预测能力.
主要成果:
- 在CRC样本中观察到物种多样性增加和明显的核酸和核酸生物合成途径.
- 在参与者中确定了三个不同的舌头涂层微生物组 (毛皮类型) 配置文件.
- 在区分CRC患者与对照群的过程中,舌膜微生物组分析实现了0.915的AUC,其中*Atopobium rimae*,*Streptococcus sanguinis*和*Prevotella oris*等物种是关键的差异化因素.
结论:
- 这项研究首次阐明了CRC患者的舌头涂层微生物组.
- 鉴定的毛皮类型提高了对人类微生物群落的理解.
- 基于舌膜微生物群的生物标志物为CRC预测和诊断提供了宝贵的参考.
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