在参考范围内的较高的自由甲状腺素水平对胆道癌症风险的保护作用:多变量孟德尔随机化和调解分析
Yuxian Chen1, Hao Dong1, Baozhen Qu2
1College of Medicine, Qingdao University, Qingdao, China.
Frontiers in endocrinology
|April 30, 2024
概括
较高的自由甲状腺素 (FT4) 水平可能会降低胆道癌症 (BTC) 的风险,可能由代谢综合征和腰围介导. 这一发现为肝胆癌的预防提供了洞察力.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 遗传学是一种遗传学.
背景情况:
- 肝胆癌 (HBC),包括肝细胞癌 (HCC) 和胆道癌 (BTC),是癌症死亡的重要原因.
- 晚期诊断HBC增加了疾病负担,突出了迫切需要有效的预防策略和风险因素的识别.
- 甲状腺荷尔蒙与HBC有关,这促使人们对其特定作用进行研究.
研究的目的:
- 评估甲状腺功能对HBC风险的因果关系.
- 调查甲状腺功能和BTC之间的关系中代谢综合征和腰围的潜在调解效应.
主要方法:
- 采用孟德尔的随机化 (MR),使用单核酸多态 (SNP) 作为仪器变量.
- 分析了来自ThyroidOmic和FinnGen联盟的数据.
- 包括单变量和多变量MR分析,其次是甲状腺功能指标 (FT4,TSH,甲状腺功能过高,甲状腺功能低下) 和HBC的中介分析.
主要成果:
- 增加的自由甲状腺素 (FT4) 水平与降低的BTC风险有显著的因果关系,但HCC没有.
- 甲状腺刺激激素 (TSH),甲状腺功能障碍和甲状腺功能障碍并没有与HBC风险产生因果关系.
- 在参考范围 (FT4-RR) 内的FT4对BTC的保护作用部分由代谢综合征 (MetS) 风险降低和腰围缩小 (WC) 介导.
结论:
- 更高的FT4-RR可能会对BTC产生保护作用,而MetS和WC则作为部分调解者.
- 这项研究强调了FT4在BTC病变发生过程中的潜在作用,并确定了MetS和WC作为重要的调解因素.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
The Thyroid Gland
3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K


