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使用光学连贯性断层扫描和光学连贯性断层扫描血管造影来界定偏头痛中的神经血管恒温:一篇综述
Devahuti R Chaliha1,2, Mauro Vaccarezza1,3, Jason Charng4,5
1Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
Frontiers in neuroscience
|April 30, 2024
概括
光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 显示了偏头痛患者的视网膜变化. 这些成像技术显示了视网膜厚度和血管密度的减少,这表明了对偏头痛诊断和理解血管变化的潜在生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 偏头痛是全球导致残疾的主要原因.
- 视网膜变化正在成为偏头痛的潜在生物标志物.
- 光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 是一种非侵入性成像技术.
研究的目的:
- 系统地审查和综合对偏头痛患者的OCT和OCTA的发现.
- 评估OCT和OCTA作为偏头痛的诊断和预后生物标志物的潜力.
- 探索视网膜变化和偏头痛亚型之间的关系.
主要方法:
- 在主要数据库 (谷歌学者,ProQuest,Scopus,科学网) 进行全面的文献搜索.
- 包括在偏头痛患者和健康对照中使用OCT和OCTA的研究.
- 对视网膜厚度,血管密度和骨无血管区面积的数据进行分析.
主要成果:
- 与对照人群相比,偏头痛患者表现出视网膜厚度 (OCT) 降低,视网膜血管密度降低,以及较大的叶无血管区面积 (OCTA).
- OCTA的研究结果表明,偏头痛患者的眼球输液受损.
- 在慢性偏头痛和带有光环的偏头痛中,缺陷更为明显.
结论:
- 作为偏头痛的客观视网膜生物标志物,OCT和OCTA显示出有前途.
- 这些成像模式可以帮助阐明与偏头痛病理生理学相关的血管变化.
- 需要进一步的纵向研究来确定因果关系,并完善诊断/治疗应用.
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