声波振动通过对IL-10的上调调节来改善炎症性疾病
Huijeong Ahn1, Eui-Man Jung2, Min-Woo Cho3
1College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea.
Animal cells and systems
|April 30, 2024
概括
声波振动疗法,特别是90 Hz,显著提高抗炎性互白素-10 (IL-10) 的产生. 这种振动疗法证明了通过增加IL-10表达来管理炎症状况的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 生理学 生理学 生理学
背景情况:
- 声波振动 (SV) 或振动声学疗法被认为可以提高血液循环和缓解疼痛.
- 根据SV的治疗益处,特别是它对炎症的影响的确切机制仍然不完全理解.
- 调查 SV 对炎症反应的影响对于其临床应用至关重要.
研究的目的:
- 研究声波振动 (SV) 对炎症反应的影响.
- 评估不同SV频率对细胞因子分泌 in vivo 和 in vitro 的影响.
- 阐明振动疗法的抗炎机制.
主要方法:
- 在小鼠模型和巨细胞培养物中诱导了炎症反应.
- 在频率为14,45和90Hz的频率上应用了SV刺激,幅度为0.5m/s2.2.
- 测量了细胞因子表达,包括互白素-10 (IL-10),以及存活率和疾病症状.
主要成果:
- 在LPS诱导的小鼠中,90Hz的SV显著增加了互白素-10 (IL-10) 分泌.
- 经过90 Hz SV刺激后,在腹膜排泄细胞和巨细胞中观察到IL-10基因表达的增加.
- 在LPS诱导的小鼠中,90 Hz SV提高了生存率,并在大肠炎模型中减轻了症状.
结论:
- 声波振动疗法,特别是90 Hz,表现出显著的抗炎作用.
- 该机制涉及显着增加IL-10表达,这是一个关键的抗炎细胞因子.
- 这项研究提供了科学证据,支持振动疗法在控制炎症疾病中的作用.
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